High-performance liquid chromatographic determination of simvastatin in medical drugs
نویسنده
چکیده
A simple and rapid HPLC method for the determination of simvastatin using a C18-Hypersil column and acetonitril–phosphate buffer–methanol (5 : 3 : 1, v/v/v) as a mobile phase with detection at 230 nm was proposed. Commercial pharmaceutical tablets were analyzed with a linear range for simvastatin up to 1.884 mg % and a regression coefficient of 0.9995. The method is found to be precise, accurate, reliable, and selective. DOI: 10.1134/S1061934806010138
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